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Abstract #1706

Multimodality Imaging in Cerebro-Cerebeller Verbal Working Memory

Wen-Yang Chiang1, Jing-Syun Yu2, Shen-Hsing Annabel Chen2, Wen-Yih Isaac Tseng3

1Research Institute, The Methodist Hospital, Houston, TX, USA; 2Department of Psychology, National Taiwan University, Taipei, Taiwan; 3Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan

A protocol of combining structural and functional images is proposed to localize the specific white matter connections between multiple activation areas. We use fMRI and DSI for this protocol to localize the in vivo evidence of white-matter connections involved in different neuronal activities in cerebro-cerebullar working memory which has not been proofed before. This in vivo technique not only enables us to discriminate the difference of adjacent white-matter structures involve in different stages of functional activations, but also prospects the vision of looking at the dynamic involvements of white-matter connections during different neuronal activities.