Abstract #1725

Time Course Information Extracted by the Sliding Window Analysis Detected the Decrease of T-Values in Hippocampal Areas During a Paired Associative Learning of Novel Faces and Names

Kayako Matsuo^1,2, Epifanio Tila Bagarinao³, Tetsuya Iidaka⁴, Akinori Takeda⁵, Toshiharu Nakai²

¹Dept. Psychology, National Taiwan University, Taipei, Taiwan; ²Dept. Gerontechnology, National Center for Geriatrics and Gerontology, Ohbu, Aichi, Japan; ³Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan; ⁴Dept. Psychiatry, Nagoya University, Nagoya, Aichi, Japan; ⁵Ministry of Health, Labour and Welfare, Chiyoda-ku, Tokyo, Japan

A new method gSliding Window Analysis (SWA)h was applied to extract a decreasing trend of t-values in hippocampal areas during fMRI. The SWA moves a statistical window to examine how the t-value changes during the session. We designed a paired associative learning of novel faces and names that were compared with famous faces and names. Young participants, specifically those with high scores, demonstrated a downward trend of the t-values, whereas the trends were obscure in the elderly participants. The decrease in the t-values suggested the establishment of the associative learning because the hippocampus is specifically involved in the memory encoding.