Abstract #1746

Structural and Functional Consequences of Ischemia and Reperfusion in the Heart - A Long-Term Follow Up Via Cardiac MRI in a Rodent Model

Florian Andreas Bnner^1,2, Stefan Weber³, Karl Friedrich Kreitner, Wolfgang Gnther Schreiber³, Georg Horstick²

¹1st Medical Clinic, Division of Cardiology, Pulmonary Disease and Vascular Medicine, University Hospital RWTH Aachen, Aachen, Germany; ²2nd Medical Clinic, Mainz University Medical School, Mainz, Germany; ³Section of Medical Physics, Department of Radiology, Mainz University Medical School, Mainz, Germany

The objective of this study was to noninvasively highlight global and local effects of ischemia and reperfusion (I/R) in a rodent model by using contrast enhanced (CE) and cine MRI based on a 1.5 Tesla clinical scanner system as a preliminary study. Rats received a more or less prolonged cardiac ischemia. SR-FLASH and SR-Turbo-FLASH sequences were used to generate perfusion, CE and cine MRI 48h and 6 weeks after I/R. Images were taken with sufficient resolution to have a valid analysis of contrast agend distribution and myocardial func-tion. This setup promises good practicability for further pathophysiological studies.