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Abstract #1749

3D Black-Blood T1 Mapping of the Mouse Heart Using IntraGate FLASH and DESPOT1 Analysis

Bram Fransiscus Coolen1, Tessa Geelen1, Arno Nauerth2, Larry de Graaf1, Klaas Nicolay1, Gustav J. Strijkers1

1Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technlogy, Eindhoven, Netherlands; 2Bruker BioSpin MRI GmbH, Ettlingen, Germany

A method for fast and robust 3D T1 quantification of the mouse heart is presented. This is based on a IntraGate FLASH retrospectively triggered steady-state sequence in combination with DESPOT1 analysis. By additionally incorporating blood saturation, flow artifacts are reduced and blood-myocardial contrast is enhanced. With this method, very homogeneous T1 maps of the mouse myocardium were obtained. This steady-state approach allowed quantification of T1 through the entire mouse heart within reasonable acquisition times.