Abstract #1755

Accurate Assessment of Myocardial Infarction in Mice Using 3D Inversion Recovery Gradient Echo MRI

Steffen Bohl^1,2, Craig A. Lygate¹, Hannah Barnes¹, Debra Medway¹, Lee-Anne Stork¹, Jeanette Schulz-Menger², Stefan Neubauer³, Juergen E. Schneider¹

¹Cardiovascular Medicine, BHF Experimental MR Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK; ²Cardiology, Franz Volhard Klinik, Charite University Medicine, HELIOS Klinikum, Berlin, Germany; ³Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK

In-vivo myocardial gadolinium pharmacokinetics were investigated in infarcted mice using rapid T1-measurements. In a second step fast high resolution three-dimensional late Gadolinium enhancement MRI was implemented using tailored latencies and inversion times for both intravenous and intraperitoneal injections of the contrast agent. Infarct sizes derived from MRI were related to the histological standard of reference.