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Abstract #1755

Accurate Assessment of Myocardial Infarction in Mice Using 3D Inversion Recovery Gradient Echo MRI

Steffen Bohl1,2, Craig A. Lygate1, Hannah Barnes1, Debra Medway1, Lee-Anne Stork1, Jeanette Schulz-Menger2, Stefan Neubauer3, Juergen E. Schneider1

1Cardiovascular Medicine, BHF Experimental MR Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK; 2Cardiology, Franz Volhard Klinik, Charite University Medicine, HELIOS Klinikum, Berlin, Germany; 3Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK

In-vivo myocardial gadolinium pharmacokinetics were investigated in infarcted mice using rapid T1-measurements. In a second step fast high resolution three-dimensional late Gadolinium enhancement MRI was implemented using tailored latencies and inversion times for both intravenous and intraperitoneal injections of the contrast agent. Infarct sizes derived from MRI were related to the histological standard of reference.