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Abstract #1757

Validation of Infarct Measurements by Inversion Recovery Delayed-Enhancement MRI During the Hyper-Acute Phase of Myocardial Infarction in Rats

King Kenneth Cheung1, Anthony Neil Price2, Roger J. Ordidge1, Mark Francis Lythgoe2

1Department of Medical Physics and Bioengineering, University College London (UCL), London, UK; 2Centre for Advanced Biomedical Imaging (CABI), Department of Medicine and Institute of Child Health, UCL, London, UK

Delayed-enhancement (DE)-MRI is a well-established method for assessing in vivo infarct size in chronic and sub-chronic myocardial infarction (MI); however its application in small animal models has been limited to sub-optimal MR sequences, and its accuracy in the hyper-acute phase (i.e. hours) of MI remains ill-defined. This abstract describes a validation of inversion recovery DE-MRI for measuring infarct size during the hyper-acute phase of MI in rats. Our results demonstrate excellent agreement between DE-MRI and TTC staining. DE-MRI can offer accurate infarct measurement at the hyper-acute phase of MI, which may serve as a valuable early marker for prognostic predictions and assessment of therapeutic outcome.