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Abstract #1760

Myocardial T1, T2 and T2* Measurements for in Vivo Assessment of Iron Overload in Thalassemia

Taigang He1, John-Paul Carpenter1, Guang-Zhong Yang2, Dudley J. Pennell1, David N. Firmin1

1Cardiovascular MR Unit, Royal Brompton Hospital and Imperial College, London, UK; 2Department of Computing, Imperial College London

This study is to compare myocardial T1, T2, and T2* measurements and their intrinsic relationship in thalassemia patients (N=48). Multi-echo T1, T2, and T2* images were acquired in the myocardium. The results demonstrate that both T1 and T2 correlate linearly with T2* in patients with iron overload, but not in patients with normal iron. The study also demonstrates a linear correlation between T1 and T2 in all the patients. This study suggests that T1, T2, and T2* can be used for assessing myocardial iron overload. For subjects with normal iron, T1 and T2 can potentially provide improved myocardial tissue characterization.