Abstract #1802

High Temporal and Spatial Resolution Cine MRI for Characterizing Valvular and Cardiac Alterations in a Genetic Mouse Model of Valve Disease

Frank Kober¹, Stphane Zaffran², Piotr Topilko³, Patrick J. Cozzone¹, Monique Bernard¹

¹Centre de Rsonance Magntique Biologique et Mdicale (CRMBM), UMR CNRS N 6612, Facult de Mdecine, Universit de la Mditerrane, Marseille, France; ²Institut de Biologie du Dveloppement de Marseille-Luminy, CNRS UMR N 6216, Marseille, France; ³Biologie Molculaire du Dveloppement, Inserm U784, ENS, Paris, France

Lessons learned from valvulogenesis may provide insight into the molecular basis of adult valvular disease. The objective of this study was to detect potential valve defects and their consequences on left ventricular (LV) function and morphology in a krox20 knockout mouse model in vivo using high-resolution cine MRI.