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Abstract #1802

High Temporal and Spatial Resolution Cine MRI for Characterizing Valvular and Cardiac Alterations in a Genetic Mouse Model of Valve Disease

Frank Kober1, Stphane Zaffran2, Piotr Topilko3, Patrick J. Cozzone1, Monique Bernard1

1Centre de Rsonance Magntique Biologique et Mdicale (CRMBM), UMR CNRS N 6612, Facult de Mdecine, Universit de la Mditerrane, Marseille, France; 2Institut de Biologie du Dveloppement de Marseille-Luminy, CNRS UMR N 6216, Marseille, France; 3Biologie Molculaire du Dveloppement, Inserm U784, ENS, Paris, France

Lessons learned from valvulogenesis may provide insight into the molecular basis of adult valvular disease. The objective of this study was to detect potential valve defects and their consequences on left ventricular (LV) function and morphology in a krox20 knockout mouse model in vivo using high-resolution cine MRI.