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Abstract #1811

Of Mice and Men: A Quantitative Comparison of 3D Cardiac Motion in Mice and Humans

Erica Dall'Armellina1, Hannah Barnes1, Stefan Neubauer1, Steffen E. Petersen1, Michael Markl2, Jurgen E. Schneider1, Bernd A. Jung2

1Department of Cardiovascular Medicine, University of Oxford, Oxford, Oxon, UK; 2University Hospital Freiburg, Freiburg, Germany

Tissue Phase Mapping (TPM) is a well-established technique to assess regional cardiac function in humans [e.g. 1,2]. In mice, time course of the radial, rotational (i.e. tangential) and longitudinal velocity components of the myocardium have not been analysed as yet. The aim of our study was to perform a detailed analysis of transmural wall motion in normal mice, and to quantitatively compare the murine velocity patterns to those found in human hearts. We found that the motion pattern of normal mouse hearts is similar to the human heart, but the peak velocities in mice are a factor of ~3 lower for all velocity components compared to humans. Furthermore, the velocity twist in humans during systole between basal and more apical slices is inverted in mice