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Abstract #1817

Assessment of Three Dimensional Left Ventricular Strain After VEGF Gene Therapy in Occlusive Infarction on Magnetic Resonance Imaging

Maythem Saeed1, Marcus Carlsson1,2, Demetrius Dicks1, Alastair Martin1, David Saloner1

1UCSF, Dep of Radiology and Biomedical Imaging, San Francisco, CA, USA; 2Lund University Hospital, Dep of Clinical Physiology, Lund, Sweden

Transendocardial delivery of vascular endothelial growth factor gene in infarcted and peri-infarcted myocardium under MR-guidance improved 3D (radial, circumferential and longitudinal) strain within 50 days and caused significant reduction in infarct transmurality of treated animals compared to controls. Cine and tagging MRI are sensitive techniques for monitoring the effects of locally delivered therapies.