Abstract #1856

Investigating the Potential of MRI as a New Non-Invasive Modality for Wave Intensity Analysis (WIA) in Healthy and Renal Disease Subjects

Celine Quinsac¹, Alan Jackson², Philip Kalra³, Helen Eddington³, Paul Dark³

¹Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences , The University of Manchester, Manchester, UK; ²Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, The University of Manchester, Manchester, UK; ³School of Translational Medicine, The University of Manchester, Manchester, UK

This work investigated the potential to perform systemic arterial input Wave Intensity Analysis (WIA) using one-dimensional MR blood velocity measurements in the ascending aorta taken in association with blood pressure waveforms recorded using wrist applanation tonometry. Wave Intensity Analysis (WIA) was performed in both healthy volunteers and patients with chronic renal dysfunction already known to have increased arterial stiffness. Using these non-invasive measurement modalities, WIA was successful in showing higher systolic blood pressure, wave reflection and wave speed in the patient group, indicators of decreased arterial compliance.