Abstract #1859

In Vivo Measurement of Regional and Local Pulse-Wave Velocity in Mice with MRI at 17.6 T

Volker Herold¹, Marco Parczyk¹, Gert Klug², Wolfgang Rudolf Bauer², Peter Michael Jakob¹, Eberhard Rommel¹

¹Department of Experimental Physics 5, University of Wrzburg, Wrzburg, Germany; ²Medizinische Universittsklinik, University of Wrzburg, Wrzburg, Germany

In this work we present two different methods to non-invasively examine the pulse-wave velocity (PWV) at different sites in the murine aorta: a regional multipoint-transit-time (TT) method and a local flow-area (QA) approach. MR experiments were validated with a deformable vessel wall phantom. The in vivo PWV values measured with the MR-technique showed good agreement with values stated in literature measured using Doppler ultrasound. While the multipoint TT-approach allows to assess local and regional PWV changes in the descending aorta, the local QA-approach is useful to detect early vascular abnormalities at locations such as the ascending aorta.