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Abstract #1859

In Vivo Measurement of Regional and Local Pulse-Wave Velocity in Mice with MRI at 17.6 T

Volker Herold1, Marco Parczyk1, Gert Klug2, Wolfgang Rudolf Bauer2, Peter Michael Jakob1, Eberhard Rommel1

1Department of Experimental Physics 5, University of Wrzburg, Wrzburg, Germany; 2Medizinische Universittsklinik, University of Wrzburg, Wrzburg, Germany

In this work we present two different methods to non-invasively examine the pulse-wave velocity (PWV) at different sites in the murine aorta: a regional multipoint-transit-time (TT) method and a local flow-area (QA) approach. MR experiments were validated with a deformable vessel wall phantom. The in vivo PWV values measured with the MR-technique showed good agreement with values stated in literature measured using Doppler ultrasound. While the multipoint TT-approach allows to assess local and regional PWV changes in the descending aorta, the local QA-approach is useful to detect early vascular abnormalities at locations such as the ascending aorta.