Impact of Timing and Dose of Isosorbide Dinitrate Administration on Coronary MRI

Peng Hu¹, Dana C. Peters¹, Kraig V. Kissinger¹, Beth Goddu¹, Lois Goepfert¹, Warren J. Manning¹, Reza Nezafat¹

In this study, we investigate the impact of sublingual isosorbide dinitrate on SNR, vessel diameter, vessel sharpness and overall image quality in coronary MRI as a function of time, dose and imaging sequence. Isosorbide dinitrate improves coronary MRI SNR by 20% for both GRE and SSFP imaging. Compared to 2.5mg dose, the 5mg dose results in higher SNR, comparable vasodilation that occurs earlier and with greater vessel sharpness scores. The 5mg dose is therefore preferred.