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Abstract #1913

Differences in Skeletal Muscle Lipid Metabolism in Upper and Lower Extremities by Localized Correlated Spectroscopy

Steven L. Lindauer1, John Austin Vargo1, Steven Coon2, Raymond R. Raylman1, M. Albert Thomas3, Richard G. Spencer4, Stephen E. Alway5, S. Sendhil Velan1

1Center for Advanced Imaging and Department of Radiology, West Virginia University, Morgantown, WV, USA; 2Section of Digestive Diseases, Department of Medicine, West Virginia University, Morgantown, WV, USA; 3Radiology, UCLA, Los Angeles, CA, USA; 4Magnetic Resonance Imaging and Spectroscopy Section, NIA, National Institutes of Health, Baltimore, MD, USA; 5Department of Exercise Physiology, West Virginia University, Morgantown, WV, USA

We have investigated the skeletal muscle lipid metabolism in upper and lower extremities. Our preliminary measurements of intramyocellular lipids in upper and lower extremities indicate differences in their accumulation which might be due to the different physical activity pattern for the two extremities. The forearms might be less prone to the development of insulin resistance due to greater involvement in daily physical activities.