Abstract #1913

Differences in Skeletal Muscle Lipid Metabolism in Upper and Lower Extremities by Localized Correlated Spectroscopy

Steven L. Lindauer¹, John Austin Vargo¹, Steven Coon², Raymond R. Raylman¹, M. Albert Thomas³, Richard G. Spencer⁴, Stephen E. Alway⁵, S. Sendhil Velan¹

¹Center for Advanced Imaging and Department of Radiology, West Virginia University, Morgantown, WV, USA; ²Section of Digestive Diseases, Department of Medicine, West Virginia University, Morgantown, WV, USA; ³Radiology, UCLA, Los Angeles, CA, USA; ⁴Magnetic Resonance Imaging and Spectroscopy Section, NIA, National Institutes of Health, Baltimore, MD, USA; ⁵Department of Exercise Physiology, West Virginia University, Morgantown, WV, USA

We have investigated the skeletal muscle lipid metabolism in upper and lower extremities. Our preliminary measurements of intramyocellular lipids in upper and lower extremities indicate differences in their accumulation which might be due to the different physical activity pattern for the two extremities. The forearms might be less prone to the development of insulin resistance due to greater involvement in daily physical activities.