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Abstract #1916

Progression of Fat Infiltration in Calf, Thigh and Pelvic Muscles in Duchenne Muscular Dystrophy: Quantification by MRI Over an 18 Month Period

Kieren Grant Hollingsworth1, Penelope Garrood2, Benjamin Segun Aribisala1, Daniel Birchall3, Michelle Eagle2, Kate Bushby2, Volker Straub2

1Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle, Tyne and Wear, UK; 2Institute of Human Genetics, Newcastle University, Newcastle, Tyne and Wear, UK; 3Regional Neurosciences Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, Tyne and Wear, UK

Knowledge of the progression of fatty infiltration is important in designing therapy trials for Duchenne Muscular Dystrophy. 11 ambulant boys with DMD (age at recruitment 6.6-9.9 years) were studied at 0, 9 and 18 months. T1-weighted imaging was performed of the muscles of the calf, thigh and pelvis, and T2 measurements were made of the thigh muscles, to track the progress of fatty infiltration. T1w imaging was related to the bone marrow intensity and showed greater progression in the pelvis and thigh muscles than the calf (except gracilis). T2 measurement confirmed progression in all muscles of the thigh.