Abstract #1916

Progression of Fat Infiltration in Calf, Thigh and Pelvic Muscles in Duchenne Muscular Dystrophy: Quantification by MRI Over an 18 Month Period

Kieren Grant Hollingsworth¹, Penelope Garrood², Benjamin Segun Aribisala¹, Daniel Birchall³, Michelle Eagle², Kate Bushby², Volker Straub²

¹Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle, Tyne and Wear, UK; ²Institute of Human Genetics, Newcastle University, Newcastle, Tyne and Wear, UK; ³Regional Neurosciences Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, Tyne and Wear, UK

Knowledge of the progression of fatty infiltration is important in designing therapy trials for Duchenne Muscular Dystrophy. 11 ambulant boys with DMD (age at recruitment 6.6-9.9 years) were studied at 0, 9 and 18 months. T1-weighted imaging was performed of the muscles of the calf, thigh and pelvis, and T2 measurements were made of the thigh muscles, to track the progress of fatty infiltration. T1w imaging was related to the bone marrow intensity and showed greater progression in the pelvis and thigh muscles than the calf (except gracilis). T2 measurement confirmed progression in all muscles of the thigh.