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Abstract #1924

Similarity Between Deoxyhemoglobin Concentration and R2 Time Course During Isometric Dorsiflexion

Christopher Paul Elder1, Marti Ann Chance1, Ryan N. Cook2, Bruce M. Damon1,2

1Radiology and Radiological Sciences and Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA; 2Biomedical Engineering, Vanderbilt University, Nashville, TN, USA

There is a need to develop MR techniques to measure oxygen extraction in skeletal muscle. The purpose of this study was to determine if R2 and deoxyhemoglobin concentration ([Hb]) exhibit similar time course during submaximal isometric contraction. Six subjects performed a 120s submaximal isometric dorsiflexion while [Hb], R2*, R2 were measured. The R2 and [Hb] time courses showed excellent similarity in 3 subjects and dissimilarity in another 3. Similarity exists in subjects with free perfusion while dissimilarity exists in subjects with limited perfusion during contraction. <