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Abstract #1952

Localized Correlated Spectroscopy of Bone Marrow: Determination of Unsaturation and Apoptosis

S. Sendhil Velan1, Steven L. Lindauer1, John Austin Vargo1, Steven Coon2, Raymond R. Raylman1, Ravinder R. Regatte3, Vazhaikkurichi M. Rajendran2, Richard G. Spencer4

1Center for Advanced Imaging and Department of Radiology, West Virginia University, Morgantown, WV, USA; 2Section of Digestive Diseases, Department of Medicine, West Virginia University, Morgantown, WV, USA; 3Center for Biomedical Imaging and Department of Radiology, NYU Medical Center, New York, NY, USA; 4Magnetic Resonance Imaging and Spectroscopy Section, NIA, National Institutes of Health, Baltimore, MD, USA

There is a great interest in developing approaches for non-invasive investigation of bone marrow due to its importance in osteoporosis. Degree of unsaturation and apoptosis are highly relevant for diagnosis and treatment interventions of osteoporosis. In this work, we have implemented localized two-dimensional correlated spectroscopic technique to demonstrate the in vivo determination of degree of unsaturation and apoptosis. We have measured the degree of unsaturation and apoptosis in 8 normal-weight subjects.