Johan Grankvist1, Rune V. Fisker1, Victor Vishwanath Iyer2, Finn Taagehj Jensen1, Ernst-Torben Frnd1,3, Carsten Wiberg Simonsen1, Thorkil Christensen1, Lars Stenbygaard4, Marianne Ewertz Kvistgaard4,5, Elna-Marie Larsson1
1Department of Radiology, Aalborg
Hospital / Aarhus University Hospital, Aalborg, Denmark; 2Department
of Nuclear Medicine, Aalborg Hospital / Aarhus University Hospital, Aalborg,
Denmark; 3GE Healthcare - Applied Science Laboratory Europe; 4Department
of Oncology, Aalborg Hospital / Aarhus University Hospital, Aalborg, Denmark; 5Department
of Oncology, Odense University Hospital, Odense, Denmark
This project compares 3T MRI and 18-FDG-PET/CT in patients with bone metastases from breast cancer to the spine and pelvis.
The tissue phase variations between grey and white matter are thought to originate from either tissue susceptibility variations or variations of macromolecule content affecting the water chemical shift. In this abstract we test these two hypotheses by trying to fit a high resolution fieldmap with the expected spatial distribution calculated after segmentation of a high resolution T1 weighted image. Results tentatively suggest the dominance of a non-susceptibility origin.