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Abstract #2010

Gravimetric Validation of Lung Density Measured by Multi-Image Gradient Echo Quantitative MRI

Sebastiaan Holverda1, Susan Hopkins1,2, Tatsuya J. Arai1, G. Kim Prisk1,2, Rebecca J. Theilmann3

1Medicine, University of California, San Diego, USA; 2Radiology, University of California, San Diego, USA; 3Radiology, University of California, San Diego, San Diego, CA, USA

A multi-image gradient echo sequence that collects data at two echo times was shown to produce highly reproducible values of lung density in vivo that were found to be consistent with previous studies. It was unknown whether these values represent absolute water content. The goal of this work was to validate our imaging technique against absolute water content measured gravimetrically using excised pig lungs as a model. Imaging results were well correlated and within 9% of actual gravimetric values.