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Abstract #2039

True-SEEPAGE: A Tool for Evaluating Renal Perfusion and Function

Karan Dara1,2, Jamal J. Derakhshan1,2, Andre Fischer3, Stephen R. Yutzy1,2, Nicole Seiberlich2, Jeffrey L. Duerk1,2, Mark A. Griswold1,2, Vikas Gulani1,2

1Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA; 2Radiology, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH, USA; 3Physikalisches Institut, University of Wurzburg, Germany

True-SEEPAGE is a non-subtraction non-contrast based segmented imaging technique which can be used to study renal perfusion and function while avoiding the problem of Nephrogenic Systemic Fibrosis that may be associated with Gd-based contrast agents. In True-SEEPAGE, the stationary tissue is saturated and the unsaturated spins from inflowing are imaged, giving rise to a true perfusion signal in the kidney. Observed perfusion is seen as a function of renal arterial blood flow. This technique may, in the future, be used to detect and characterize tumors in the kidney without the administration of contrast agents.