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Abstract #2074

The Hepatic Uptake of Gd-EOB-DTPA Is Strongly Affected by the Hepatobiliary Function

Olof Dahlqvist Leinhard1,2, Nils Dahlstrm1,2, Per Sandstrm3, Anna Freij4, Johan Kihlberg2, Torkel Brismar5, rjan Smedby1,2, Peter Lundberg1,2

1Department of Medical and Health sciences, Linkping University, Linkping, Sweden; 2Center for Medical Image Science and Visualization (CMIV), Linkping University, Linkping, Sweden; 3Department of Surgery, Linkping University, Linkping, Sweden; 4Radiation Physics, Linkping University Hospital, Linkping, Sweden; 5Karolinska University Hospital, Stockholm, Sweden

The late hepatic uptake of Gd-EOB-DTPA was quantified in 10 healthy subjects and 21 patients with suspected hepatobiliary disease. A strong reduction in contrast concentration in the liver was observed in late phases in patients with impaired hepatobiliary function. The uptake also showed a strong correlation with clinical liver status scores (MELD and Child-Pugh). The results indicate that it is possible to assess hepatobiliary function within a clinical MRI protocol by measuring hepatic uptake of Gd-EOB-DTPA.