Abstract #2074

The Hepatic Uptake of Gd-EOB-DTPA Is Strongly Affected by the Hepatobiliary Function

Olof Dahlqvist Leinhard^1,2, Nils Dahlstrm^1,2, Per Sandstrm³, Anna Freij⁴, Johan Kihlberg², Torkel Brismar⁵, rjan Smedby^1,2, Peter Lundberg^1,2

¹Department of Medical and Health sciences, Linkping University, Linkping, Sweden; ²Center for Medical Image Science and Visualization (CMIV), Linkping University, Linkping, Sweden; ³Department of Surgery, Linkping University, Linkping, Sweden; ⁴Radiation Physics, Linkping University Hospital, Linkping, Sweden; ⁵Karolinska University Hospital, Stockholm, Sweden

The late hepatic uptake of Gd-EOB-DTPA was quantified in 10 healthy subjects and 21 patients with suspected hepatobiliary disease. A strong reduction in contrast concentration in the liver was observed in late phases in patients with impaired hepatobiliary function. The uptake also showed a strong correlation with clinical liver status scores (MELD and Child-Pugh). The results indicate that it is possible to assess hepatobiliary function within a clinical MRI protocol by measuring hepatic uptake of Gd-EOB-DTPA.