Olof Dahlqvist Leinhard1,2, Nils Dahlstrm1,2, Per Sandstrm3, Anna Freij4, Johan Kihlberg2, Torkel Brismar5, rjan Smedby1,2, Peter Lundberg1,2
1Department of Medical and Health sciences, Linkping University, Linkping, Sweden; 2Center for Medical Image Science and Visualization (CMIV), Linkping University, Linkping, Sweden; 3Department of Surgery, Linkping University, Linkping, Sweden; 4Radiation Physics, Linkping University Hospital, Linkping, Sweden; 5Karolinska University Hospital, Stockholm, Sweden
The late hepatic uptake of Gd-EOB-DTPA was quantified in 10 healthy subjects and 21 patients with suspected hepatobiliary disease. A strong reduction in contrast concentration in the liver was observed in late phases in patients with impaired hepatobiliary function. The uptake also showed a strong correlation with clinical liver status scores (MELD and Child-Pugh). The results indicate that it is possible to assess hepatobiliary function within a clinical MRI protocol by measuring hepatic uptake of Gd-EOB-DTPA.