Abstract #2089

Vascular Bed Volume Change of Uterine Fibroids After GnRHa Treatment: Assessment with Gadolinium-Enhanced Dynamic R2* Imaging

Shigeo Okuda¹, Koichi Oshio¹, Akihiro Tanimoto¹, Hironori Asada², Masahiro Jinzaki¹, Ayano Akita¹, Hirotaka Akita¹, Tomonori Hada³, Masataka Furuya⁴, Hiroshi Shinmoto⁵, Yasunori Yoshimura⁴, Sachio Kuribayashi¹

¹Department of Diagnostic Radiology, Keio University School of Medicine, Shinjyuku-ku, Tokyo, Japan; ²Department of Obstetrics and Gynecology, Keio University School of Medicine, TokyoTokyo, Japan; ³Department of Obstetrics and Gynecology, Keio University School of Medicine, Japan; ⁴Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan; ⁵Department of Radiology, National Defense Medical College, Saitama, Japan

The purpose of our study is to assess vascular bed volume change of uterine fibroids after GnRHa treatment by using Gadolinium-enhanced dynamic R2* imaging (R2*I). Double-echo fast SPGR sequence was utilized to generate R2*I. A total of 25 patients was assessed with R2*I before and after the treatment. We measured area-under-the-curve (AUC) of signal intensity curve in selected ROI (3x3 cm) on R2*I, and compared AUCs of the first and second examinations. Although increase of AUC value was observed in four patients, the mean values of AUC were decreased from 40.2 to 19.0 with significant difference (p<.0001, paired t test).