Wouter B. Veldhuis1, Chunlei Liu1, Roland Bammer1, Bruce L. Daniel1, Michael E. Moseley1
1Dept of Radiology / Lucas MRI Center, Stanford University, Palo Alto, CA, USA
With increasing resolution the readout time for conventional single-shot diffusion-weighted echo-planar imaging (DW-EPI) lengthens to the point that blurring and geometric distortions impair image acquisition. Here we compare high-resolution 256x256 multi-shot breast-DW MRI using SNAILS, to DW-EPI with parallel imaging. Free-breathing, axial, bilateral DW-data sets were acquired in 6 healthy volunteers at 1.5T. SNAILS allowed distortion free acquisition of 2562 data sets, not possible with DW-EPI, even with parallel imaging. Comparison of apparent diffusion coefficient (ADC) values at 1282 resolution, showed that ADCs obtained with DW-EPI are lower than those obtained with SNAILS, with identical b-value combinations.