Three Dimensional 1H Magnetic Resonance Spectroscopy in Breast Cancer as an Indicator of Therapy Response. a Pilot Study

Stephan Gruber¹, Wolfgang Bogner², Marek Chmelik, Katja Pinker, Lothar Ponhold, Martin Krssak, Siegfried Trattnig

In this study, a high resolution 3D-MRSI protocol at 3 Tesla was used in female breast cancer patients before and after treatment (chemotherapy). In total, three patients were scheduled for two or three measurements. In two patients Cho was detectable before treatment, but, after treatment, the Cho resonance was no longer detectable. In one patient Cho was detectable in all three measurements with variable SNR. Approaches for absolute quantification are necessary for future applications, which would allow more reliable monitoring of the response to chemotherapy in breast cancer.