Abstract #2144

Liver MRI and MRS for Hepatic Fat Determination in a Multicenter Clinical Trial: Evaluation of Exam Quality in Academic and Non-Academic Centers

Mark Rosen¹, Sarah Englander¹, Harish Poptani¹, Evan Siegelman¹, James Gimpel², Dena Flamini², Matthew Parris³, Bill Sasiela³, Bruce Hillman^4,5

¹Radiology, University of Pennsylvania, Philadelphia, PA, USA; ²American College of Radiology Imaging Network, Philadelphia, PA, USA; ³Aegerion, Inc., Bridgewater, NJ, USA; ⁴Radiology, University of Virginia, Charlottesville, VA, USA; ⁵American College of Radiology, Phialdelphia, PA, USA

A fifteen-center multisite trial of hepatic MRI and MRS for liver fat determination in 470 subjects was performed for the phase II evaluation of the MTP inhibitor AEGR-733. Sites performed single voxel MRS and multiple dual-echo GRE imaging for quantifying hepatic fat. Both academic and non-academic sites were included. Analyzable MRS data was obtained in 96.3% of cases. Fully compliant MRI data sets were obtained in 90.0% of cases. Both academic and non-acadeimc sites performed equally well with respect to MRS quality. Academic sites submitted a higher percentage of protocol-compliant MRI data sets than did non-academic sites.