Metabolic Profiles of Urine and Serum from Type 2 Diabetic Mice Detected by 1H NMR Spectra

Jingjing Xu¹, Jiyang Dong¹, Shuhui Cai¹, Zhong Chen¹

Information of the whole endogenous metabolic variations caused by type 2 diabetes mellitus is of great value for discovering the primary aetiological factor of diabetes mellitus. Here metabolic profiles of urine and serum samples from type 2 diabetic mice of 8 weeks old were studied by H-1 NMR spectra together with principal components analysis. Both samples can be discriminated clearly from the control group. A number of characteristic metabolites contributed to class separation were identified and analyzed. These results indicate significant alterations in metabolic profiles of urine and serum at the insulin resistance stage of type 2 diabetic animals.