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Abstract #2179

Assessment of Regional Alterations of Lung Function and Structure by Hyperpolarized 3He MRI in a Murine Model of Emphysema

Kiarash Emami1, John MacDuffie-Woodburn1, Charles J. Kotzer2, Gregory A. Logan2, Stephen Kadlecek1, Jianliang Zhu3, Stephen Pickup1, Jiangsheng Yu1, Matthew Stetz1, Masaru Ishii4, Michael Stephen5, Patricia L. Podolin2, Rahim Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, USA; 2Respiratory Center of Excellence for Drug Discovery, GlaxoSmithKline, King of Prussia, PA, USA; 3Division of Thoracic Surgery, University of Pennsylvania, Philadelphia, PA, USA; 4Department of Otolaryngology – Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, USA; 5Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, Philadelphia, PA, USA

The sensitivity of two HP 3He MRI-based measurements of gas diffusivity and ventilation to elastase-induced changes in a murine model of emphysema are studied in this work. The motivation is primarily the increasing interest in assessment of pulmonary disease models, and in assessment of therapeutic interventions in transgenic murine disease models, thereby making it necessary to extend functional and structural lung imaging techniques to a smaller scale.