Abstract #2185

Regional Analysis of Gas Elimination and Redistribution in Lungs During High Frequency Oscillatory Ventilation Studied with Hyperpolarized 3He MRI

Maxim V. Terekhov¹, Alexander W. Scholz², Julien Rivoire¹, Lars Lillpopp², Ursula A. Wolf¹, Wolfgang Schreiber¹

¹Department of Radiology, Section of Medical Physics, Mainz University Medical School, Mainz, Germany; ²Department of Anesthesiology, Mainz University Medical School, Mainz, Germany

MRI using hyperpolarized helium-3 as a contrast gas allows studying lung air-spaces in high temporal and spatial resolution. Applying this imaging technique we aimed to quantify the regional time constants of the inert gas elimination by high-frequency oscillatory ventilation (HFOV). Additionally, we strived at the time constants of regional redistribution within the lungs using regional and pixel based mapping.