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Abstract #2185

Regional Analysis of Gas Elimination and Redistribution in Lungs During High Frequency Oscillatory Ventilation Studied with Hyperpolarized 3He MRI

Maxim V. Terekhov1, Alexander W. Scholz2, Julien Rivoire1, Lars Lillpopp2, Ursula A. Wolf1, Wolfgang Schreiber1

1Department of Radiology, Section of Medical Physics, Mainz University Medical School, Mainz, Germany; 2Department of Anesthesiology, Mainz University Medical School, Mainz, Germany

MRI using hyperpolarized helium-3 as a contrast gas allows studying lung air-spaces in high temporal and spatial resolution. Applying this imaging technique we aimed to quantify the regional time constants of the inert gas elimination by high-frequency oscillatory ventilation (HFOV). Additionally, we strived at the time constants of regional redistribution within the lungs using regional and pixel based mapping.