Abstract #2201

Modeling Dead Space in Measurements of Pulmonary Ventilation Using Hyperpolarized 3He MRI

KiaRash Emami¹, Masaru Ishii^1,2, Stephen Kadlecek¹, John MacDuffie-Woodburn¹, Jianliang Zhu³, Stephen Pickup¹, Jiangsheng Yu¹, Matthew Stetz¹, Michael Stephen⁴, Rahim Rizi¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, USA; ²Department of Otolaryngology – Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, USA; ³Division of Thoracic Surgery, University of Pennsylvania, Philadelphia, PA, USA; ⁴Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, Philadelphia, PA, USA

The dead space volume in measurements of lung ventilation using gaseous contrast agents can be a substantial source of error if their magnitude is not carefully incorporated in the gas distribution model. This work presents a three-compartment model to include both static and dynamic dead volumes of the ventilation and pulmonary system and to correct for their effects in regional measurements of lung ventilation using hyperpolarized 3He MRI.