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Abstract #2209

Hyperpolarized 129Xe Lung MRI with TrueFISP on Spontaneous Breathing Mice by Means of Continuous Delivery of Xe Gas Polarized Under Low Pressure

Hirohiko Imai1,2, Fumito Imai2, Tsuyoshi Ito2, Ryosuke Kashiwagi2, Toshio Kadobayashi2, Atsuomi Kimura2, Hideaki Fujiwara2

1Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan; 2Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

Hyperpolarized 129Xe trueFISP images are examined on spontaneous breathing mice using the low-pressure and continuous-flow type 129Xe polarizer toward the development of a fully non-invasive method for lung functional imaging. With the aid of the fast imaging sequence and the high-performance 129Xe polarizer, temporal resolution and SNR have been extremely improved in the resulting images. By exploiting these characteristics, 129Xe lung images at maximum inspiratory and expiratory phases were successfully obtained from rapidly breathing mice.