Abstract #2211

Chemical Shift Imaging of the Lungs with Hyperpolarized Xe-129: Results from a Rabbit Model of Stereotactic Lung Radiosurgery with and Without a Radioprotector.

Jaime Mata¹, Ke Sheng², Paul Read², Kai Ruppert¹, Klaus Hagspiel¹, Talissa Altes¹, William Tobias³, Gordon Cates³, James Brookeman¹, John Mugler III¹

¹Radiology, University of Virginia, Charlottesville, VA, USA; ²Radiation-Oncology, University of Virginia, Charlottesville, VA, USA; ³Physics, University of Virginia, Charlottesville, VA, USA

Recently it was shown that an optimized version of a CSI pulse sequence can produce images of hyperpolarized Xe-129 with high in-plane spatial resolution during a single breath-hold. Here, we used the same sequence to evaluate a rabbit model of lung stereotactic-radiation surgery with and without a radioprotector. Xe-129 CSI detected radiation-induced pulmonary injury at 4 and 8 weeks post-treatment, and was able to detect reduced early treatment toxicity as a result of a clinically used radioprotector. This study again demonstrated the feasibility of optimizing CSI for Xe-129 to obtain spatially-localized spectral data from the lung in a breath-hold acquisition.