Abstract #2221

Evaluation of Computer Aided 3D Parametric Analysis of MR-Mammography for Follow-Up Assessment of Malignant Lesions Under Primary Systemic Therapy

Lale Umutlu¹, Stefan Maderwald¹, Till A. Heusner¹, Sherko Kuemmel², Rainer Kimmig², Elke Hauth¹, Michael Forsting¹, Thomas C. Lauenstein¹

¹Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, NRW, Germany; ²Department of Gynaecology and Obstetrics, University Hospital Essen, Essen, NRW, Germany

Apart from non-melanoma skin cancer, breast cancer is currently the most common cancer type among women. In case of multricentric or inoperable tumor manifestation neoadjuvant chemotherapy is used for preoperative tumor size reduction. Hence, the evaluation of early treatment response is an inevitable issue in primary systemic therapy. Computer aided detection systems provide a fast and reliable determination of tumor volume, as well as changes in further, important follow-up markers, by means of contrast kinetics, vascular permeabilitiy and extracellular volume fraction. Thus, CAD systems enable valid assessment of early treatment response under neoadjuvant chemotherapy.