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Abstract #2223

Parametric Response Mapping: A Voxel-Based Analysis of Quantitative Diffusion MRI Changes for Individualized Assessment of Primary Breast Cancer Response to Therapy

Chuck Meyer1, Thomas Chenevert, Craig Galban, Timothy Johnson, Daniel Hamstra, Alnawaz Rehemtulla, Brian Ross

1University of Michigan, Ann Arbor, MI, USA

This paper presents preliminary evidence supporting feasibility of using three ADC MRI interval acquisitions, two pre- and one post-therapy initiation to determine response to neoadjuvant chemotherapy within two weeks. This was a double blinded study where the clinical oncologists clinical assessment of response to the first cycle of chemotherapy was compared to quantitative estimates of increased intra-tumoral diffusion. The use of parametric response mapping (PRM), a voxel-by-voxel change analysis, demonstrated 100% accuracy in the initial feasibility study of 5 primary breast cancer patients.