Nagarajan Rajakumar1, Ana Maria Gomez1, Daniel Margolis1, Steven S. Raman1, Timothy McClure1, Michael Albert Thomas1
1Radiological Sciences, UCLA, Los Angeles,
CA, USA
Proton magnetic resonance spectroscopic imaging (MRSI) is a promising method
for detecting prostate carcinomas showing higher choline and reduced citrate
levels in comparison with healthy prostate tissues. 28 prostate cancer patients
with different Gleason score is derived from robotic-assisted prostatectomy
(GS) underwent endorectal MRSI.There was a significant difference between the
(Cho+Cr)/Cit ratio of groups with four different GS (3+3, 3+4, 4+3, 4+4). Low
GS shows decreased citrate where as high GS have further decreased or absent
citrate and increasing choline. This pilot work demonstrates that changes in
relative metabolite levels provided by MRSI can be a non invasive indicator of
grade of malignancy.
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