Ramkrishnan Narayanan1, John Kurhanewicz2, Katsuto Shinohara2, David Crawford3, Albaha Barqawi3, Anne Simoneau4, Jasjit Suri1
1Engineering, Eigen Inc., Grass Valley, CA, USA; 2University of California, San Francisco, CA, USA; 3University of Colorado, Denver, CO, USA; 4University of California, Irvine, CA, USA
Conventional ultrasound imaging guided biopsy cannot detect prostate cancer with sufficient sensitivity, and up to 40% of prostate cancers are iso-echoic. T2-weighted magnetic resonance imaging using endorectal coil combined with pelvic phased-array coil provides high resolution images of the prostate with high sensitivity of identifying cancer. A key challenge in using MRI with ultrasound for improving prostate biopsy procedures is their registration. We describe our preliminary registration experiment using two multimodality phantoms with six and twelve glass beads embedded (fiducials). Preoperative MRI and ultrasound are registered using a nonlinear deformation model, and registration error is reported.