Josephine Helen Naish1, Deirdre M. McGrath2, Lauren J. Baines1, Katia Passera3, Caleb Roberts1, Sue Cheung1, M Ben Taylor4, John P. Logue4, David L. Buckley1, Jean Tessier5, Helen Young5, John C. Waterton1,5, Geoff J. Parker1
1Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, University of Manchester, Manchester, UK; 2Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada; 3Dipartimento di Ingegneria Biomedica, Politecnico di Milano, Milan, Italy; 4Christie Hospital, Manchester, UK; 5AstraZeneca, Macclesfield, Cheshire, UK
DCE-MRI biomarkers are increasingly used in cancer clinical trials. DCE-CT is a widely available alternative which provides an independent measure of closely related parameters and is more robustly modelled due to the direct relationship between contrast agent concentration and signal intensity. In this study we compare parameters derived using DCE-MRI and DCE-CT in ten patients with primary bladder cancer. Median values for both Ktrans and ve were in good quantitative agreement with CoVs of 21% and 15% respectively, comparable to that typically achieved in repeat DCE-MRI studies.