Gurpreet Singh Kapoor1, Timothy Gocke1, Sanjeev Chawla2, Ali Nabavizadeh2, Robert G. Whitmore1, Harish Poptani2, Joanna Lopinto1, Justin Plaum1, Eileen Maloney-Wilensky1, Elias R. Mehlem2, Donald M. O'Rourke1
1Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA; 2Radiology, University of Pennsylvania, Philadelphia, PA, USA
We utilized MR perfusion-weighted imaging to correlate rCBV with the angiogenic markers and EGFR gene amplification in 39 patients with cytogentically distinct oligodendroglial neoplasms. In grade II 1p19q LOH (Group 1) tumors, rCBV values were higher than 1p19q intact (Group 2) tumors. All high-grade tumors, including EGFR-amplified subtype (15%), showed higher rCBV than low-grade tumor. The mRNA levels of VEGF, CD31 and CD105 were higher in Group 1 than Group 2, independently of the EGFR-amplified subtype. Collectively, our data demonstrate that advancements in MR imaging may facilitate molecular subtyping and define distinct angiogenic profiles in cytogenetic subsets of oligodendroglial tumors.
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