Yi-Ying Wu1, Ho-Ling Liu2,3
1Institute of Medical Physics and Imaging Science, Chang Gung University, Kwei-Shan , Tao-Yuan, Taiwan; 2Institute of Medical Physics and Imaging Science, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan; 3MRI Center, Chang Gung Memorial Hospital, Kwei-Shan, Taoyuan, Taiwan
In the DSC MRI of brain tumors, previous investigations found elevated tracer concentration during the recirculation phases and interpreted as the degree of vascular tortuosity or contrast extravasations in the tumors. In principle, the contrast leakage can appear as additive or subtractive effects to the intravascular recirculation. This study proposed a model to separate the intravascular and the extravasation components during the recirculation phase. The results showed difficulties to extract vessel permeability information from DSC time curves, when there are co-exist intravascular components. Although the contrast leakage during the first-pass was observed in our simulation, its sensitivity requires further studies.