Abstract #2300

Dynamic Contrast-Enhanced MR Imaging Detected Early Changes in Vascular Permeability Following Anti-DR5 Antibody Therapy in Breast Tumor Xenografts

Hyunki Kim^1,2, Karri Folks¹, Lingling Guo³, James George³, Yanhui Sun⁴, Kurt Zinn¹

¹Radiology, University of Alabama at Birmingham, Birmingham, AL, USA; ²Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA; ³Surgery, University of Alabama at Birmingham, Birmingham, AL, USA; ⁴Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA

We performed sequential DCE-MRI every 24 hours over 3 days, detecting significantly lower Ktrans levels in breast tumors responsive to anti-DR5 antibody, anti-VEGF antibody, and combination therapies. Sequential DCE-MRI may provide a sufficient number of data points to enable non-linear mathematical modeling for vascular permeability changes; the non-linear characteristics could be considered as a time-independent imaging biomarker. Further, the novel technique of localizing the tumor region of interest to a 0.5-mm peripheral region enhances Ktrans quantification accuracy markedly and can be translated to clinical trials immediately. The proposed techniques may be utilized to improve Personalized Medicine during breast-tumor preoperative therapy.