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Abstract #2303

Effect of Vascular Targeting on Tumor Vessel Volume and Size Distribution

Thomas Nielsen1,2, Lise Bentzen1, Michael Pedersen3, Michael Robert Horsman1, Leif stergaard2

1Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark; 2Center of Functionally Integrative Neuroscience, Department of Neuroradiology, Aarhus University Hospital, Aarhus, Denmark; 3MR Research Center, Aarhus University Hospital, Aarhus, Denmark

The vascular disrupting agent combretastatin A-4 disodium phosphate (CA4DP) acts on dividing endothelial cells. We hypothesize that CA4DP affects tumor vessels of particular sizes. The aim of this study was to evaluate the effect of CA4DP by vessel size imaging in murine C3H mammary carcinomas. Histograms of blood volume and vessel radius showed general decrease in blood volume and reduction of vessels with radii in a certain range in treated animals compared to controls. VSI may on sight be valuable in estimation of tumor angiogenic status and prediction of response to vascular disrupting agents.