Abstract #2327

Diffusion MRI of Choroid Melanoma Tumor in Mouse Eye

Peng Sun¹, Huiying Zhang², Qing Wang³, Gregory M. Lanza², Sheng-Kwei Song¹, Samuel A. Wickline², Junjie Chen⁴

¹Radiology, Washington University in St. Louis, Saint Louis, MO, USA; ²Internal Medicine, Washington University in St. Louis, Saint Louis, MO, USA; ³Mechanical, Aerospace and Structural Engineering, Washington University in St. Louis, Saint Louis, MO, USA; ⁴Internal Medicine , Washington University in St. Louis, Saint Louis, MO, USA

Choroidal melanoma is the most common intraocular malignancy. The objective of the present study is to quantify apparent diffusion coefficient (ADC) of choroidal melanoma for tumor identification in mice. Mice underwent intraocular inoculation of 5010³ B16F10 melanoma cells were imaged at 11.74T. Three-direction diffusion weighted images were acquired to derive the ADC map. Tumor mass could be clearly indentified on the ADC map due to the higher ADC of melanoma tumor (0.6510^-3 mm²/s) than that of the retina (0.3610^-3 mm²/s). The results suggested diffusion weighted MRI could detect choroidal melanoma in vivo.