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Abstract #2335

In Vivo T2 Measurements of Glioma Growth in Mouse Brain at 9.4T

Barbara Blasiak1,2, Boguslaw Tomanek1,3, Tadeusz Foniok3, Dave Kirk1, Abedelnasser Abulrob4,5, Umar Iqbal5, Danica Stanimirovic4,5, Xuequing Lun1, Peter Forsyth1, Garnette Sutherland1

1Dept of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada; 2Polish Academy of Sciences, Institute of Nuclear Physics, Krakow, Malopolska, Poland; 3Institute for Biodiagnostics (West), National Research Council of Canada, Calgary, Alberta, Canada; 4Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada; 5Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada

The correlation between T2 and the intracranial growth of U87MG deltaEGFR cells in nude mice, as a model of human high grade glioma, was investigated. MSME images of the growing tumor were acquired 10 to 13 days after the injection. We observed that the difference in T2 in the early stage of the tumor growth (< 2 mm3) between cancerous and normal tissue was less than 10%. The difference increased to about 20% when the tumor was larger (> 2.5 mm3). The results provide valuable information about MR imaging strategies, including molecular imaging, at the early stage of cancer development.