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Abstract #2362

Diffusion Measurement of Mobile Lipids Using Co-Resonant Coupled Metabolite Dephasing

Gerd Melkus1, Philipp Mrchel1, Michael Flentje2, Peter Michael Jakob1,3

1Experimental Physics 5, University of Wrzburg, Wrzburg, Germany; 2Radiation Oncology, University of Wrzburg, Wrzburg, Germany; 3Research Center for Magnetic Resonance Bavaria (MRB), Wrzburg, Germany

A frequency selective spin-echo method for Mobile Lipids (ML) detection in the 0.5-2.5 ppm area is presented where an additional selective pulse on the lactate and alanine methine (CH) groups minimizes the lactate and alanine methyl (CH3) contamination to the ML signal. The metabolite signal dephasing is based on their J-coupling and is therefore independent of relaxation times. Pulsed field gradients were applied for diffusion measurement of the ML. The method was tested on a lactate/alanine and oil phantom. Diffusion weighted measurements of lactate free ML signal at ~1.3 ppm were successfully accomplished on xenograft tumor models.