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Abstract #2378

Subcutaneous Lipid Suppression Via Variable-Density Spiral Sampling for Full Cortical Coverage in Chemical Shift Imaging

Joonsung Lee1, Borjan Gagoski1, Michale Hamm2, Elfar Adalsteinsson1,3

1Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA; 2Siemens Medical Solutions USA, Inc, Cambridge, MA, USA; 3Harvard-MIT Division of Health Sciences of Technology, Massachusetts Institute of Technology, Cambridge, MA, USA

Estimates of metabolites in the brain using large-FOV CSI are severely hampered by strong interfering lipid signals arising from subcutaneous tissue. A novel approach using variable-density sampling in k-space with accompanying proportional filtering is presented. Healthy volunteers were scanned on a 3T Siemens Trio scanner with a 32-channel head coil. The variable spiral trajectory was implemented with a conventional PRESS excitation of 3-cm thick axial section with a voxel size of 0.47 cc, and FOVxy = 24 cm, FOVz= 6.2cm, in a scan time of 16 min. Even in peripheral regions of the cortex, NAA is distinguishable from the lipids.