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Abstract #2425

Comparison of HMQC and Dynamic Nuclear Polarization for Detection of 13C Tracers in the Perfused Mouse Heart

Crystal Harrison1,2, A Dean Sherry3,4, Craig R. Malloy5,6, Matthew E. Merritt7,8

1Physics, University of Texas at Dallas, Richardson, TX, USA; 2AIRC, UTSW, Dallas, TX, USA; 3AIRC, UTSW Medical Center, Dallas, TX, USA; 4Chemistry, University of Texas at Dallas, Richardson, TX, USA; 5AIRC, AIRC, Dallas, TX, USA; 6Cardiology, North Texas VA Hospital, Dallas, TX, USA; 7Advance Imaging Research Center, UT Southwestern Med. Center, Dallas, TX, USA; 8Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA

The proliferation of mouse models of human pathologies has driven a need for increased sensitivity in MRS. Proton detection of [3-13C]pyruvate is compared to direct detection of hyperpolarized [1-13C]pyruvate in the perfused mouse heart. HMQC does not suffer from loss of polariation due to T1, but lacks the ability to measure oxidative metabolism.