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Abstract #2428

Secondary Substrate Assisted Dynamic Nuclear Polarization

Albert P. Chen1, Charles H. Cunningham2, David M. Wilson3, Susan J. Kohler4, John Kurhanewicz3, Daniel B. Vigneron3, Ralph E. Hurd5

1GE Healthcare, Toronto, ON, Canada; 2Sunnybrook Health sciences centre, Toronto, ON, Canada; 3Radiology, UCSF, San Francisco, CA, USA; 4Union College, Schenectady, NY, USA; 5GE Healthcare, Menlo Park, CA, USA

To achieve high polarization enhancement in a short time, MR probes polarized via DNP have been limited to substrates with low molecular weight and high solubility in organic solvent/water. But it may be possible to enhance the polarization of a target substrate that has poor DNP properties (low solubility, poor enhancement) with a secondary substrate that demonstrates high DNP enhancement and can be added in high concentration, allowing the secondary nuclei to assist the polarization of the target nuclei via spin diffusion. This technique was tested in this study with 13C urea as the secondary substrate.