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Abstract #2434

Hyperpolarized 13C MRS in the Rat Brain: Spatial Origin of Signals

Malgorzata Marjanska1, Isabelle Iltis1, Dinesh K. Deelchand1, Michael Garwood1, Pierre-Gilles Henry1

1Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, USA

The low sensitivity of 13C spectroscopy can be enhanced using dynamic nuclear polarization (DNP) technique. Detection of [1-13C]pyruvate and its metabolic products have been reported in kidney, liver, muscle, and brain. In this work, we investigate the spatial origin of [1-13C]pyruvate and [1-13C]lactate signals in rat brain.