Malgorzata Marjanska1, Isabelle Iltis1, Dinesh K. Deelchand1, Michael Garwood1, Pierre-Gilles Henry1
1Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, USA
The low sensitivity of 13C spectroscopy can be enhanced using dynamic nuclear polarization (DNP) technique. Detection of [1-13C]pyruvate and its metabolic products have been reported in kidney, liver, muscle, and brain. In this work, we investigate the spatial origin of [1-13C]pyruvate and [1-13C]lactate signals in rat brain.