Pratip Bhattacharya1, Eduard Y. Chekmenev1, Shawn Wagner1, Henry R. Chan1, William H. Perman2, Alan Epstein3, Brian D. Ross4
1Enhanced MR Laboratory, Huntington Medical Research Institutes, Pasadena, CA, USA; 2School of Medicine, St. Louis University, St. Louis, MO, USA; 3Department of Pathology, University of Southern California, Los Angeles, CA, USA; 4Enhanced MR Laboratory, Huntington Medical Research Institutes, Pasadena, Pasadena, CA, USA
Succinate can be now be hyperpolarized at over 20% level of polarization routinely and reproducibly in our laboratory. Succinate is biomedically interesting as it can potentially assess the in vivo activity of succinate dehydrogenase (SDH), the enzyme that was recently tagged as an oncogene due to its crucial role in cell energetics. This abstract describes the application of hyperpolarized succinate for imaging cancer in different tumor models in mice.
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