Eric T. Peterson1, Matthew G. Erickson2, Sean B. Fain2, Ian J. Rowland3
1Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, USA; 2Medical Physics, University of Wisconsin - Madison, Madison, WI, USA; 3Radiology, University of Wisconsin - Madison, Madison, WI, USA
This work presents a method for concentrating a hyperpolarized compound prior to injection. By replacing 75% of the water in a typical dissolution with a chemically and biologically inert liquid that is immiscible with water, the injected volume can be readily reduced to approximately 1.5 ml. This provides a more concentrated solution shortening injection time for an equivalent dose while flushing a sufficient volume of fluid through the system. This is demonstrated for 13C labeled pyruvic acid, but may be applied to any compound hyperpolarized by the DNP method.