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Abstract #2449

Development of a Fast Field-Cycling Method for Polarizing C13 Using Parahydrogen-Induced Polarization

Aaron K. Grant1, Elena Vinogradov1

1Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA

In parahydrogen-induced polarization (PHIP), carbon-13 polarization is usually obtained using field cycling techniques or RF pulse sequences. Field cycling techniques are simple but relatively slow, whereas RF pulse techniques are faster but require more sophisticated hardware. Here we present studies of a simple field cycling method that employs a modified time-dependent field pattern to achieve high levels of polarization in a short time. We present theoretical computations to show that the method should be capable of yielding high polarization levels in a few tens of milliseconds, and preliminary data that qualitatively support the theoretical expectations.